Safety of Ovarian Cryopreservation and Transplantation in Nude Mice Bearing Human Epithelial Ovarian Cancer

The treatments of ovarian cancer mainly include surgery and chemotherapy. After surgery, patients will lose ovarian function permanently. A considerable portion of patients with epithelial ovarian cancer are women of childbearing age. The loss of ovarian function will lead to a serial of clinical symptoms or metabolic syndrome (Michelsen et al., 2009). The patients’ quality of life suffers severely (Finch and Narod., 2011). At present, the common approach is hormone replacement therapy (HRT). However, researches about the application of HRT to patients with epithelial ovarian cancer after surgery are rare. Its security has not been systematically certified by bulk of clinical researches. Clinical application is subject to certain restriction (MacLennan, 2011). Therefore, it is necessary to find a more safe and effective way to solve the problem that patients with epithelial ovarian cancer lose ovarian function after surgery.